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Acetylcholinesterase inhibitors for diagnosed cognitive impairment, stimulant medications for ADHD under prescriber supervision, or lifestyle interventions (aerobic exercise, sleep optimization, dietary management) with robust clinical evidence

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[55] In individuals with obesity, chronic low-grade inflammation often leads to "leptin resistance"a pathological state where circulating leptin levels are high, but the brain fails to register the signal, leading to persistent hunger